How Cordyceps Fights Cancer?
Oct 04, 2022
Cancer is one of the leading causes of deaths and still needs an appropriate remedy. C. militaris has brought about an evolutionary change in Pharmacognosy, leading to establish a viable base for treating cancer. Electrophoresis analysis and gel filtration has shown it’s inhibitory effect on viability of cancer cells like MCF-7, IC50. It has also proved it’s anti proliferative effects on breast cancer cells(MCF-7). C. militaris might be able to inhibit cancer growth through regulation of p85/AKT-dependent or GSK3β-related caspase-3-dependent apoptosis. Different Cordyceps species have been studied to elucidate pharmacological activity including anti-inflammatory, antioxidant, antifungal, and anticancer activity. Cordyceps sinensis species inhibits growth of U937 leukemia, A549 lung cancer, and B16 melanoma cells. · Cordyceps militaris inhibits growth of HepG2 liver hepatocellular carcinoma cells.
Therefore, previous results indicate that Cordyceps species have potent anticancer activity against diverse cancer types including leukemia, melanoma, lung carcinoma, and liver carcinoma.
The conclusion was drawn that inhibition of cell proliferation and further apoptosis of SW480 and SW620 cells were induced by cordycepin the main component of Cordyceps.Similar action of cordycepin was also demonstrated in gallbladder cancer cells in vitro with its additional effect in down regulation of multidrug resistance (MDR) expression.Its mode of action was by activation of AMPK (adenosine monophosphate activated protein kinase) signaling which resulted in degradation of MDR/ HIF-1α (hypoxia inducible factor), cordycepin inhibited the mTORC1 (mammalian target of rapamycin complex 1) in gallbladder cancer cell which leads to loss of cancer cell viability and apoptosis. *MDR/HIF-1α and mTORC1 are factor responsible for chemo resistance.Improvised complex of Selenium and CS (Se-CS) was produced and experimented its efficacy in treating Uterine cervix cancer Ethanol extract of Cordyceps militaris was highly cytotoxic to human colorectal carcinoma RKO cells and inhibited the growth of tumor . The anti-tumor effect of Cordyceps militaris was associated with an induction of cell cycle arrest and mitochondrial-mediated apoptosis.