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CORDYCEPS ACTING AS ANTI-OXIDANTS

Oct 04, 2022


Researchers believe their antioxidant content may explain their anti-ageing potential.Supplements and products containing Cordyceps extract have become increasingly popular due to their many purported health benefits.Cordyceps Sinensis is one of the most valued herbs in traditional Chinese medicine. We investigated the antioxidant activities of the cultured fruiting bodies of Cordyceps Sinensis. The water and ethanol extracts of Cordyceps Sinensis were found to possess a potent antioxidant activity.The scavenging effects of the extracts on superoxide were very weak, but the extracts moderately inhibited malondialdehyde formation via hydroxyl radical-induced by SIN‐1, a peroxynitrite generator. Of the extracts examined, the hot water extract (70 °C for 5 min) showed the greatest oxygen-free radical scavenging activity. Also, when low‐density lipoprotein (LDL) was incubated with macrophages in the presence of CuCl2 (1 µM ), the hot water extract showed a strong inhibitory effect against lipid peroxidation in the medium and consequent accumulation of cholesteryl ester in macrophages. These results suggest that the extracts of cultured Cordyceps Sinensis possess potent antioxidant activities.CPS1 had been isolated from C. Sinensis mycelium by hot water extraction, ethanol precipitation, anion exchange, and gel permeation chromatography. The results indicated that CPS1 was a glucomannogalactan with the monosaccharide composition of glucose: mannose: galactose = 2.8: 2.9: 1. The total carbohydrate content of CPS1 was 99.0%. The weight-average molecular weight was 8.1 x 10(3) Da. The results predicted (1-->2) and (1-->4)-linkage of mannose, (1-->3)-linkage of galactose, (1--> ) and (1-->3, 6)-linkage of glucose composed the backbone of CPS1. CPS1 was also evaluated for its antioxidant activity in vitro, including scavenging effects on the hydroxyl radicals, the reducing power, Fe(2+)-chelating activity, scavenging effect on superoxide radicals, as well as the inhibition of hydrogen peroxide-induced haemolysis. CPS1 showed a high antioxidant effect, especially the scavenging effect of hydroxyl radicals, the reducing power and Fe(2+)-chelating activity. The results provide scientific support for the antioxidant activity.REFERENCES:https://www.sciencedirect.com/science/article/pii/S014181301300127X   

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